The sciFLEXARRAYER piezo dispenser is a non-contact liquid handling and spotting system, which dispenses with a high dynamic volume range (picolitre to microlitre). It is designed as a tool for the automated ultra-low volume handling of biological samples, e.g. DNA, proteins or cells. The non-contact, piezo-electric liquid handling station can use up to eight individually configurable, chemically inert dispense modules, mounted to a high precision X-Y-Z stage. In this moment, the equipment only has one dispense module. The dispense module can accurately aspirate and dispense aqueous as well as organic solutions to a broad range of substrates. Sample solutions are provided in individual vials or on 96 or 384 well microtitre plates. An optimized, low-volume wash station, including ultrasonication excludes cross-contamination when a new sample is aspirated. A high-resolution optical drop control station monitors the performance of each dispense capillary.